منابع مشابه
SURVIVAL IN PATIENTS WITH MALIGNANT GLIOMAS OF THE BRAIN
The present retrospective study was designed to analyze factors with prognostic values a) within, and b) significantly associated with, short-term (12months or less) and long-term (more than 24 months) survival times, i n 72 consecutive patients treated for malignant gliomas. Among 41 (57%) short-term surviving patients, the absence of both aphasia and motor deficit (as initial presenting ...
متن کاملMalignant gliomas in adults.
Copyright © 2008 Massachusetts Medical Society. Malignant gliomas account for approximately 70% of the 22,500 new cases of malignant primary brain tumors that are diagnosed in adults in the United States each year.1-3 Although relatively uncommon, malignant gliomas are associated with disproportionately high morbidity and mortality. Despite optimal treatment, the median survival is only 12 to 1...
متن کاملMicroRNAs in Human Malignant Gliomas
MicroRNA (miRNA) is a new class of small noncoding RNA molecules that regulate a wide spectrum of gene expression in a posttranscriptional manner. MiRNAs play crucial roles in tumorigenesis, angiogenesis, invasion, and apoptosis for various types of tumor. Recent studies have identified dysregulation of specific miRNAs in malignant gliomas. Global expression profiling of miRNAs has revealed sev...
متن کاملThe Different Role of Notch1 and Notch2 in Astrocytic Gliomas
It is well known that Notch signaling plays either oncogenic or tumor suppressive role in a variety of tumors, depending on the cellular context. However, in our previous study, we found that Notch1 was overexpressed while Notch2 downregulated in the majority of astrocytic gliomas with different grades as well as in glioblastoma cell lines U251 and A172. We had knocked down Notch1 by siRNA in g...
متن کاملImmunohistochemical Study of CD68 and CR3/43 in Astrocytic Gliomas
Diffuse and high-grade astrocytomas are invasive neoplasms which grow diffusely into the brain parenchyma. Microglia has been termed the brain’s immune system, although its specific role remains uncertain. Objective of this study was to assess in a series of astrocytic neoplasms, the expression of a macrophage marker CD 68 and Major Histocompatibility Complex Class II CR3/43. We examined 10 pil...
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ژورنال
عنوان ژورنال: Cancer
سال: 1990
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19900615)65:12<2771::aid-cncr2820651227>3.0.co;2-j